ACTH action on podocytes: mystery solved?
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چکیده
1 2 3 4 5 6 7 8 Editorial focus: 9 10 ACTH action on podocytes: mystery solved? 11 12 13 Paolo Cravedi and Kirk N Campbell 14 15 Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York 16 17 18 Running title: Melanocortins and podocytes 19 20 21 22 23 24 25 Word count: 947 26 27 28 29 30 31 32 33 34 35 Correspondence to: 36 Kirk N Campbell, MD 37 Division of Nephrology, Icahn School of Medicine at Mount Sinai 38 One Gustave L. Levy Place, Box 1243 39 New York, NY 10029 40 e-mail: [email protected] 41 42 43 44 45 46 Articles in PresS. Am J Physiol Renal Physiol (March 9, 2016). doi:10.1152/ajprenal.00139.2016
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ACTH action on podocytes: mystery solved?
PODOCYTES are the key target cell for injury in proteinuric kidney disorders such as focal segmental glomerulosclerosis (FSGS), minimal change disease, and membranous nephropathy. Sadly, advances in elucidating the molecular architectural details of the podocyte actin cytoskeleton, cell body, and intervening slit diaphragm have not yet translated into targeted therapeutic agents for clinical us...
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Nephrotic syndrome, characterized by massive proteinuria, is caused by a large group of diseases including membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS). Although the underlying mechanisms are beginning to unravel, therapy is unspecific and far from efficient. It has been suggested that adrenocorticotropic hormone (ACTH) has beneficial effects in patients with MN and...
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Melanocortin therapy by using adrenocorticotropic hormone (ACTH) or non-steroidogenic melanocortin peptides attenuates proteinuria and glomerular injury in experimental glomerular diseases and induces remission of nephrotic syndrome in patients with diverse glomerulopathies, even those resistant to steroids. The underlying mechanism remains elusive, but the role of melanocortin 1 receptor (MC1R...
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BACKGROUND AND OBJECTIVE Adrenocorticotropic hormone (ACTH) is able to reduce proteinuria in nondiabetic glomerulopathies through activation of melanocortin receptors (MCR) expressed in the podocyte. To determine the efficacy of ACTH, we conducted a randomized, open-label pilot trial of ACTH gel in patients with advanced diabetic nephropathy. STUDY DESIGN Twenty-three (23) patients with diabe...
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